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Representative histological sections of Daf-/- and WT mice infected with PR8-HK4,6, PR8-HK6, and PR8-HK4.

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posted on 2021-07-01, 17:24 authored by Nuno Brito Santos, Zoé Enderlin Vaz da Silva, Catarina Gomes, Celso A. Reis, Maria João Amorim

C57BL/6J WT and Daf-/- mice were mock infected (A) or infected with 1000 PFU of PR8-HK4,6 (B), 20 PFU of PR8-HK6 (C) and 100 PFU of PR8-HK4 (D). Samples were collected at the indicated time points.

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    PLOS Pathogens

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    Keywords

    Complement Decay-Accelerating Factorcomplement activationcomplement decay-accelerating factorNA-dependent DAF removalHAhost resiliencelung immunopathologyproteins hemagglutininIAV infectionsNA actssialylated DAFDAF potentiates complement activationSARS-CoV -2modulating complement activationsialic acidscomplement pathway bridgesDAF modulates IAV infectionzoonotic influenza transmissionsT cellsvirus lung immunopathology Clearancenon-specific complement attacksurface protein

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