pgen.1010012.s002.tif (132.82 kB)
Relative retinal pigmented epithelium (RPE) area of data presented in Fig 2A.
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posted on 2022-01-18, 18:42 authored by Jonathan Delhermite, Lionel Tafforeau, Sunny Sharma, Virginie Marchand, Ludivine Wacheul, Ruben Lattuca, Simon Desiderio, Yuri Motorin, Eric Bellefroid, Denis L. J. LafontaineRelative retinal pigmented epithelium (RPE) area (Kolmogorov-Smirnov test, **** = p<0.0001, ** = p<0.01).
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six developmental stagesfunctional ribosomal subunitsevery living cellessential nanomachines responsiblediv >< pneural crest cellsncc survival causedindividual embryos indicatedearly developmental defectsrrna 2 ’-fbl knockdown leadsearly embryonic developmentxenopus laevis 18s rrna production2 ’-xenopus laevis rrna processingprotein productionneural platencc derivativesfibrillarin knockdowndeveloping embryos28s rrnax fbl validated orthogonallyusing ribomethseqthree positionsspecific positionsnew onesnccs ),methyltransferase fibrillarinmethylated positionsmassive p53including 10frog developmentefficient predependent apoptosiscraniofacial skeletoncraniofacial developmentcalled ribosomopathiesbox cbioinformatic screening>, confirming
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