pone.0259375.g002.tif (515.46 kB)
Relationships between brain structure and other disease markers.
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posted on 2021-11-05, 17:27 authored by Catherine A. Spilling, Mohani-Preet K. Dhillon, Daniel R. Burrage, Sachelle Ruickbie, Emma H. Baker, Thomas R. Barrick, Paul W. JonesPlots showing the relationship between: Brain Tissue Volume, median CBF and Blood Pressure (panel A); WMH volume, hs-CRP and Blood Pressure (panel B); and White Matter Microstructure, Respiratory Function and troponin T (panel C) for COPD (green) and CAD (blue) patients. The adjusted r2 goodness of fit is presented for the whole cohort. Data has been adjusted for age and sex. CBF = cerebral blood flow, hs-CRP = high-sensitivity C-Reactive Protein, WMH = white matter hyperintense lesion.
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xlink "> measuresxlink "> changeswhite matter microstructureretinal vessel tortuosityretinal vessel calibrereactive protein (<principal component analysisbrain tissue volumescognitive decline occurseveral markers couldrelated diseases maycoronary artery diseasebrain changes associatedsingle common pathway47 cad ).related diseasesbrain structuresingle variablesalso occurunivariate relationshipsunclear whetherplasma lipidsorgan systemsindependent correlatehigher cglucose dysregulationfindings suggestdisease markerscopd ).composite markerscommon mechanismcad ),blood pressure100 participants
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