pgen.1009802.s002.tif (397.57 kB)
Reconstitution of EL in the liver of Lipg-/- mice.
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posted on 2021-09-20, 17:46 authored by Sumeet A. Khetarpal, Cecilia Vitali, Michael G. Levin, Derek Klarin, Joseph Park, Akhil Pampana, John S. Millar, Takashi Kuwano, Dhavamani Sugasini, Papasani V. Subbaiah, Jeffrey T. Billheimer, Pradeep Natarajan, Daniel J. RaderA-F. Plasma cholesterol (A), HDL-C (B), nonHDL-C (C), triglycerides (D), phospholipids (E), and nonesterified fatty acids (F) in WT mice treated with AAV Null, Lipg-/- mice treated with AAV Null, and Lipg-/- mice treated with AAV murine Lipg for 5 weeks after 4 weeks of feeding a high fat diet. Plasma was collected after 4 hours of fasting and lipids were measured by autoanalyzer. *P<0.05, **P<0.01, ***P<0.001, repeated measure 2-way ANOVA compared to the WT AAV Null group. Data is expressed as mean ± S.E.M.
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vital energy sourcestgs harboring longprovide fatty acidsfatty acids used>< sup ><data positions elhydrolyzing trl tgsmice demonstrated accumulationmediate efficient lipolysisfunction missense variantexcess dietary tgdiv >< pgenetic el loss>el reconstitutionel lipolysis>, eltrl metabolismtrl clearancevivo vitro rich lipoproteinsprimary rolepostprandial plasmalipoprotein lipaselipoprotein classeslipidomic analyseslipg key collaboratorfat fedendothelial lipasecirculating reservoirs>, p
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