Receiver operating characteristic (ROC) curves for predicting 90 days mortality in methicillin-sensitive Staphylococcus aureus bacteremia (N = 339).

Matrix metalloproteinase 8 (MMP-8), matrix metalloproteinase 8 and tissue inhibitor of metal- loproteinase-1 ratio (MMP-8 / TIMP-1) and C-reactive protein (CRP) were measured at day 3 (N = 395) and 5 (N = 378) past positive blood cultures. Patients with chronic renal failure were excluded (N = 57) due to low initial MMP-8 concentrations. For day 3 the MMP-8 area under the curve (AUC) was 0.58 (95% Cl 0.49–0.67) (p-value NS). For day 3 MMP-8 / TIMP-1 ratio the AUC was 0.57 (95% Cl 0.48–0.66) (p-value NS). For day 5 MMP-8 the AUC was 0.61 (95% Cl 0.52–0.69) (p<0.05) with cut-off value 149 ng/ml and sensitivity 65% and specificity 54%. For day 5 MMP-8 / TIMP-1 ratio the AUC was 0.59 (95% Cl 0.49–0.68) (p-value NS). For day 3 and day 5 CRP the AUCs were 0.47 (95% Cl 0.38–0.56) and 0.48 (95% Cl 0.39–0.57) (both p-values NS). NS = non-significant.

(TIF)