Receiver operating characteristic (ROC) curves for predicting 14 days mortality in methicillin-sensitive Staphylococcus aureus bacteremia.

Matrix metalloproteinase 8 (MMP-8), matrix metalloproteinase 8 and tissue inhibitor of metalloprotein- ase-1 ratio (MMP-8 / TIMP-1) and C-reactive protein (CRP) were measured at day 3 (N = 395) and 5 (N = 378) past positive blood cultures. Patients with chronic renal failure were excluded (N = 57) due to low initial MMP-8 concentrations. For day 3 the MMP-8 area under the curve (AUC) was 0.70 (95% Cl 0.57–0.82) (p<0.01) with cut-off value 203 ng/ml and sensitivity 68% and specificity 60%. For day 3 MMP-8 / TIMP-1 ratio the AUC was 0.68 (95% Cl 0.55–0.80) (p<0.01) with cut of value 0.87 and sensitivity 74% and specificity 56%. For day 5 MMP-8 the AUC was 0.76 (95% Cl 0.65–0.87) (p<0.001) with cut-off value of 239 ng/ml with sensitivity 74% and specificity 70%. For day 5 MMP-8 / TIMP-1 ratio the AUC was 0.75 (95% Cl 0.63–0.87) (p<0.001) with cut-off valué 1.02 and sensitivity 79% and specificity 66%. For day 3 and day 5 CRP the AUCs were 0.51 (95% Cl 0.40–0.63) (p = 0.85) and 0.53 (95% Cl 0.40–0.66) (both p-values non-significant).