pone.0279085.g004.tif (1.61 MB)
Rate of insulin secretion over the 60-min test period in women according to MR-determined percentage pancreatic fat (PPF) cut off (≥ 4.5% pancreatic fat–solid diamond, dash lines; < 4.5% pancreatic fat–solid triangle, solid line, A) and incremental area under the curves (iAUC) for first- and second-phase insulin response determined for each pancreatic fat sub-group (B, C).
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posted on 2022-12-30, 19:04 authored by Ivana R. Sequeira, Wilson Yip, Louise W. Lu, Yannan Jiang, Rinki Murphy, Lindsay D. Plank, Garth J. S. Cooper, Carl N. Peters, Benjamin S. Aribsala, Kieren G. Hollingsworth, Sally D. PoppittThe change from baseline (Δ) peak first-phase ISR (0.03 ± 0.03 nmol min-1 m-2) was significantly greater (p = 0.01) than the Δ peak second-phase ISR (0.01 ± 0.03 nmol min-1 m-2).
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visceral adipose tissuelow (< 4insulin secretion ratebiphasic insulin secretionsecond phase isrquantified pancreatic fatdysglycaemia may warrantbaseline analyte concentrations04 units lowerppf x timelow ppf groupshigh ppf valueshigh (≥ 40001 ), insulininsulin secretionpancreatic fatppf maytwo groupst2dm ),given timedysglycaemia basedxlink ">without t2dmwave stepsvs using 25significantly associatedsalient featurepreliminary investigationplasma glucosemin squareincremental areasincreased significantlyhyperglycaemia generatedhence dataethnic differencesemerging roleearly stagescompare changesclinical importancebody compositionassociated decreaseassessed isranthropomorphic variables47 %)05 ).&# 8805
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