figshare
Browse
pgen.1009992.s008.tiff (5.11 MB)

Rapamycin restores intestinal progenitor cells (IPCs) in PGRP-SAseml mutants.

Download (5.11 MB)
figure
posted on 2022-01-10, 18:27 authored by Shivohum Bahuguna, Magda Atilano, Marcus Glittenberg, Dohun Lee, Srishti Arora, Lihui Wang, Jun Zhou, Siamak Redhai, Michael Boutros, Petros Ligoxygakis

In the anterior midgut (see schematic), IPCs were reduced in PGRP-SAseml mutants. Addition of rapamycin was able to restore them. This is a representative result from 15 guts.

(TIFF)

History

Usage metrics

    PLOS Genetics

    Categories

    Keywords

    results give insightsenabled fat catabolismdiv >< prestored bacterial densityintestinal bacterial densitymaintain indigenous bacteriabacterial recognition upstreamtoll activated 4eκb signalling resultedbacterial recognitionreduced densitydownstream signallinggut bacteriacommensal bacteriatranscriptional targettoll activitypharmacological inhibitionmetabolic parametershealthy fliesgut setsfeedback loopdrosophila >, deficiency

    Licence

    CC BY 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC