pone.0248034.s009.tif (1.1 MB)
RORγt inhibitors reduce Bclxl expression in thymus of rodents.
figure
posted on 2021-11-09, 18:32 authored by Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael EllisC57Bl/6 female mice were dosed PO with 100 mg/kg Compound 1, 2 or 3. Thymic tissues were collected from separate cohorts at 2, 8, 16 and 24 hours post-dose (n = 3 mice/timepoint). RNA was extracted from thymic tissues and Bclxl expression measured by QPCR. Data are normalized to housekeeping gene (Gapdh) and displayed as relative quantification. Time zero (‘0’) used as normalization timepoint and set to 1.0 RQ and mean set at 100% for % inhibition calculation. One-way ANOVA with Bonferroni correction for multiple comparisons used for statistical significance calculations.
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retinoic acid receptorpancreatic ductal adenocarcinomadiv >< pattractive therapeutic targetassociated gene expressionnumerous autoimmune diseasesdelay tumor volumeinhibit th17 differentiationinhibit tumor formationrorγt block th17tumor formationautoimmune disorderstumor growthtumor effectsth17 cellsvivo vitro transcription factorsrorγt inhibitorsrorγt functionsprimary functionpreclinical modelsimmune responsesdependent mannercritical regulator17a production
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