pone.0248034.s007.tif (554.89 kB)
RORγt inhibitor inhibits IL-17A production in IMQ-treated ear tissue.
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posted on 2021-11-09, 18:32 authored by Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael EllisIL-17A cytokine levels were measured by Luminex assay from the supernatants of ear tissue ‘floats’ cultured for 24 hours ex vivo. Each symbol represents an individual animal and error bars denote mean ± SEM. Statistical significance (*p ≤ 0.05) was determined using one-way ANOVA with Tukey’s multiple comparisons test, *significant over naïve; **significance over vehicle-treated group. Data are representative of 2 independent experiments with n = 3-8/group.
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retinoic acid receptorpancreatic ductal adenocarcinomadiv >< pattractive therapeutic targetassociated gene expressionnumerous autoimmune diseasesdelay tumor volumeinhibit th17 differentiationinhibit tumor formationrorγt block th17tumor formationautoimmune disorderstumor growthtumor effectsth17 cellsvivo vitro transcription factorsrorγt inhibitorsrorγt functionsprimary functionpreclinical modelsimmune responsesdependent mannercritical regulator17a production
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