pone.0259643.g005.tif (472.65 kB)
Protein expression of CYP enzymes.
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posted on 2021-11-09, 18:26 authored by Nina Zemanová, Kateřina Lněničková, Markéta Vavrečková, Eva Anzenbacherová, Pavel Anzenbacher, Iveta Zapletalová, Petra Hermanová, Tomáš Hudcovic, Hana Kozáková, Lenka JourováProtein expression was measured in pooled hepatic microsomal samples of four SPF and four GF mice (0 = control, and time 2h, 6h and 24h after application of metronidazole). Protein expression of CYP enzymes was normalized to the expression of GAPDH.
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selected cytochromes p450remain mostly elusiverecent studies indicategut microbiota mayaltered gut microbiotaxlink "> microbiomegut microbiome modulatesgut microbiome affectssignificant metabolic organshown lower leveldrug metabolizing enzymesgut microbiomesignificant interactionparent drugbiotransformation enzymesvice versaresults hencereported earlierpharmacotherapy interventionsmutual relationshipmurine plasmamolecular mechanismsimmense potentialhigher levelshepatic cypscyps ).control specific30 %)
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