pone.0294282.g004.tif (1021.59 kB)
Protein-protein interactions (PPI) analysis of 24 differentially expressed aging-related genes.
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posted on 2023-11-13, 18:30 authored by Yong Zhou, Chao Sun, Yingxu Ma, Yunyin Huang, Keke Wu, Shengyuan Huang, Qiuzhen Lin, Jiayi Zhu, Zuodong Ning, Ningyuan Liu, Tao Tu, Qiming Liu(A) PPI network of 24 aging-related DEGs. The blue nodes represent the significantly up-regulated genes and the orange nodes represent the significantly down-regulated genes. The edges represent protein-protein interactions. (B) Top 10 genes identified by MCC algorithm via cytohubba. The color of the nodes represented rank. The redder the color, the higher the rank, the oranger the color, the lower the rank.
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longevity regulating pathwaykegg enrichment analysesfoxo signaling pathwayakt signaling pathwayinfiltrating immune cellsimmune cell infiltratesfunctional enrichment analysisleft atrial samplesestimate immune infiltrationcorrelation analysis revealeddifferential expression analysisdiv >< ppotential diagnostic biomarkersrelated genes associatedimmune infiltrationcorrelation analysisdiagnostic potentialatrial fibrillationscreened genesrelated genesmrna expressionexpression levelspotential agingtxn transcriptome profilessod2 significant roleroc curvesperoxisome accordingmcc algorithmsmay playmainly involvedhspa9 geo databaseessential role
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