pone.0258951.g004.tif (1.61 MB)
Protein-protein interaction network of human caveolin-1 in A549 radioresistant cells.
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posted on 2021-11-11, 18:35 authored by Dominic Leiser, Santanu Samanta, John Eley, Josh Strauss, Michael Creed, Tami Kingsbury, Paul N. Staats, Binny Bhandary, Minjie Chen, Tijana Dukic, Sanjit Roy, Javed Mahmood, Zeljko Vujaskovic, Hem D. ShuklaNetwork was constructed using STRING 10.0 database. The network shows interaction between Caveolin-1 and other important interacting protein based on experiment, co-expression, text mining & co-expression with 0.007 confidence score as the analysis parameter.
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stat signaling pathwayslung cancer patientsdiscovered higher levelcomplex multifactorial mechanismheterogeneous tumor siteradiation therapy playsradio sensitive phenotypepresent investigation caveolindiv >< pparental a549 cellsexpressed a549 cellsgene expression analysis1 overexpressed cellsradiation treatment responsea549 parentalhighly expressedenhanced expressiontumor radioresistancetumor progressiontumor aggressiontreatment failureprecision medicinepoor survivalpoor prognosisnsclc ).missense mutationmeasure caveolinmajor causedna damagedemonstrated amplificationcytoskeleton proteinsclonal selectioncas9 knockout950 pg450 pg1 protein1 1 (<
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