Prostaglandin E(PGE) does not affect total proteoglycan release
Taken from "Prostaglandin PGEat very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and , a gene linked to chondrocyte hypertrophy"
Arthritis Research & Therapy 2007;9(4):R75-R75.
Published online 7 Aug 2007
PMCID:PMC2206385.Percentage release of total proteoglycan (glycosaminoglycan (GAG) release) was measured in conditioned media of human osteoarthritic cartilage explants cultured with 5 ng/ml transforming growth factor-β2 or PGEat concentrations from 1 pg/ml to 10 ng/ml. The age and sex of each patient are indicated. Significant differences from controls (< 0.05) are indicated by asterisks.