pone.0243938.g005.tif (80.29 kB)
Proposed scheme for the effect and mechanism of FoxO1 in hepatic lipid metabolism.
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posted on 2021-01-15, 18:32 authored by Naiqian Zhao, Huiwen Tan, Li Wang, Le Han, Yanli Cheng, Ying Feng, Ting Li, Xiaoling Liu(A) FoxO1 stimulates ATGL and CGI-58 and suppresses G0S2 expression, and subsequently promotes intrahepatic lipolysis in an ATGL-dependent fashion. (B) Inhibition of FoxO1 expression by palmitate contributes to changes in hepatic triglyceride accumulation at least in part due to the inhibition of ATGL-dependent lipolysis.
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CGI -58 expressionForkhead box OG 0S expressionadipose triglyceride lipaseFoxO 1gene identification -58HepG 2 hepatoma cellsHepG 2 hepatocytes ObesityFoxO 1 overexpressionlipid accumulationNAFLDhepatic lipid accumulationtarget gene G 0S expressionPPARpalmitate-stimulated hepatic steatosisFoxO 1-mediated ATGL-dependent lipo...FoxO family members
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