pbio.3001468.s008.tif (467.85 kB)
Proposed mechanism for the conversion of 6PG to R5P.
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posted on 2021-12-03, 18:28 authored by Gabriel Piedrafita, Sreejith J. Varma, Cecilia Castro, Christoph B. Messner, Lukasz Szyrwiel, Julian L. Griffin, Markus RalserOxidant could be an electron acceptor such as oxygen or Fe(III) generated in situ. X could be a lewis acid like Fe2+ or protonated amino group from the amino acid. The pentose phosphate sugar product could be either D-Ribose-5-phosphate or D-Arabinose 5-phosphate, which are diastereomers and cannot be distinguished by LC/MS. 6PG, 6-phosphogluconate; LC/MS, liquid chromatography–mass spectrometry; R5P, ribose-5-phosphate.
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provided experimental supportchicken &# 8211proteinogenic amino acidspentose phosphate pathwaymetabolism typical temperaturedriven reaction networkcould evolution kicknonenzymatic reaction sequencesamino acidsmetabolic networkearly evolution&# 8220xlink ">vitro screeningstepwise enzymatizationsimplest componentsremain conservedrecent discoveryproviding insightsprebiotically availableppp ).phosphate formsparticular attentionoxidative pppnonenzymatic reactionslimiting stepleast partknow littlehighly conservedhigh specificityevolutionary originsenvironmental conditionsegg dilemmaadditive effectsaccelerating effects
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