Patients were divided into categories of risk using a model derived from clinical and pathological parameters at baseline: Low (n = 49), Medium (n = 9), High (n = 27), Highest (n = 14). The proportion of patients in each subset reaching primary outcome within 5 years are shown: All in each risk category (black columns); subset in each category stained positive (striped columns) or negative (white column) for C4d.