pone.0294465.g002.tif (3.32 MB)
Progressive brain deposition of Aβ plaques in APP-PS1 and J20 mice.
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posted on 2023-11-17, 18:40 authored by Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark Farrow, Andrew J. Nicoll, Dominic Walsh, John CollingeA) Representative images of APP-PS1 and J20 12-month old mice stained with 82E1b anti-Aβ antibody. Scale bar: 2 mm. B) Quantification of Aβ plaques area during aging. n = 5–8. C) Quantification of Aβ plaques number. APP-PS1 mice exhibited a higher number of plaques at 12 months of age (APP-PS1 vs J20, p = 0.014). n = 5–8.
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two mouse modelstoxic cascade elicitedlongitudinal study assessingcurrent mouse modelsj20 mouse linecommonly used j20ps1 mouse modelsoligomer profiles unalteredgiven mouse modelyielded contradictory resultsdifferent mouse modelsaβ toxicity mediateddiv >< pcellular prion proteinalzheimer &# 8217c disease accumulate amyloidaβ oligomers concomitantlydifferent modelj20 micevitro ps1 miceoligomer productionalzheimer ’&# 946amyloid βamyloid accumulationresults suggestresults provideresults obtaineddifferent targetsdifferent ratesaβ oligomersregister fibrilsoligomers formedlower levelhistological featureshigher levelsfully mimicestablished receptordistinguishes parallelcould bindcomplex diseaseclinical diseaseanalysis demonstratedalways reproducedad failad ).
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