pntd.0009937.g002.tif (209.84 kB)
Profile of AT-281 and its metabolites in plasma, lung and brain tissue after a single oral dose of AT-752.
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posted on 2022-01-24, 18:39 authored by Kai Lin, Steven S. Good, Justin G. Julander, Abbie E. Weight, Adel Moussa, Jean-Pierre SommadossiSyrian golden male hamsters were administered 500 mg/kg AT-752. Samples were collected up to 24 h post dose and analyzed for AT-281 and its metabolites by LC-MS/MS. Data are expressed as mean ± SD (n = 3 per time point).
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serum alanine aminotransferasehigh mortality ratesguanosine nucleotide analogactive triphosphate metabolite70 &# 821131 &# 956yellow fever virusdiv >< p21 days piday 6 pi6 piday 47 dayszoonotic pathogenvivo vitro virus titerviral challengeuntreated groupunexpected outbreaksreduced viremiapromising compoundpreviously identifiedpotent inhibitornormal levelsinfected animalshighest concentrationshamsters infectedfree basefold comparedeffective vaccineeffective concentrationeffective antiviraldouble prodrugclinical developmentanimal tissues4 log1000 mg001 ).
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