Gb-2007-8-3-r32-3.jpg (88.28 kB)

Principal component analysis of ion channel splice variant expression patterns for all experimental groups

figure

posted on 2011-12-31, 06:45 authored by Erin L Heinzen, Woohyun Yoon, Michael E Weale, Arjune Sen, Nicholas W Wood, James R Burke, Kathleen A Welsh-Bohmer, Christine M Hulette, Sanjay M Sisodiya, David B Goldstein

Copyright information:

Taken from "Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease"

http://genomebiology.com/2007/8/3/R32

Genome Biology 2007;8(3):R32-R32.

Published online 7 Mar 2007

PMCID:PMC1868939.

Colors separate groups based on statistical clustering (k-means clustering) of individuals with similar patterns of ion channel splicing. Colors separate groups based on disease state and brain structure: control TC (blue), mTLE NC (red), AD TC (green), control CB (black), AD CB (yellow). The first principal component explains 43% of the variation in log expression ratios, while the second principal component accounts for 13% of the variation. Separation of clusters along principal components 1 and 2 is, to a large extent, governed by brain structure and disease state.