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Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma-2

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posted on 31.12.2011, 18:21 authored by David T Yang, Ken H Young, Brad S Kahl, Stephanie Markovina, Shigeki Miyamoto
By flow cytometric analysis showing populations of (a) live cells, (b) necrotic cells, and (c) apoptotic cells. (B) Viability of Rec-1 and Jeko-1 cells treated with either 20 nM bortezomib or 0.3 mM POH for 24 hours relative to controls exposed only to vehicle shown as mean ± 1SD from triplicate wells. The unpaired -test between viability of Jeko-1 and Rec-1 cells treated with bortezomib * = 0.002 or POH **= 0.0001 were both statistically significant (< 0.01). (C) EMSAs of whole cell extracts from 1.0 × 10cells treated with 20 nM bortezomib or their respective median-effect dose of POH for 4 hours probed with P-radiolabeled oligonucleotide containing either the consensus NF-κB or Oct-1 binding sequence. Fold activity refers to NF-κB binding normalized to Oct-1 binding in each condition.

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Taken from "Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma"


Molecular Cancer 2008;7():40-40.

Published online 19 May 2008



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