Prediction of drug sensitivity using gene expression data with the pRophetic R package.

(a) Eight potential targeted and chemotherapeutic drugs significantly sensitize OBSCN mutants compared to OBSCN wild-type GBM patients. (b) The associated gene targets for drugs suggested for OBSCN mutations. (c) The effects of OSI.906 and BMS.754807, which are inhibitors of IGF-1R, on GBM patients with OBSCN and AHNAK2 Double-Mut, Single-Mut, and wild-type phenotypes.