ppat.1009165.g001.tif (2.49 MB)

Plasma responses in COVID-19 convalescent donors.

figure

posted on 2021-02-11, 18:28 authored by Michael Mor, Michal Werbner, Joel Alter, Modi Safra, Elad Chomsky, Jamie C. Lee, Smadar Hada-Neeman, Ksenia Polonsky, Cameron J. Nowell, Alex E. Clark, Anna Roitburd-Berman, Noam Ben-Shalom, Michal Navon, Dor Rafael, Hila Sharim, Evgeny Kiner, Eric R. Griffis, Jonathan M. Gershoni, Oren Kobiler, Sandra Lawrynowicz Leibel, Oren Zimhony, Aaron F. Carlin, Gur Yaari, Moshe Dessau, Meital Gal-Tanamy, David Hagin, Ben A. Croker, Natalia T. Freund

(A)-(C) Area under the curve (AUC) values for anti-SARS-CoV-2 RBD IgG (A), IgM (B) and IgA (C). Severe donors are colored in pink, Mild in light blue, and Unexposed in light gray (named “HD1-15”, samples collected prior to November 2019). Donors’ symbols are indicated on the right side of panel (D). (D) Inhibition of RBD:ACE2 binding by donors’ plasma in ELISA. All samples were normalized to the average value of the healthy donors, that was set as zero inhibition. (E)-(G) Correlation between plasma inhibition and AUC of IgG (E), IgM (F) and IgA (G). AUC and correlations (simple linear regression) were calculated using GraphPad Prism software. Statistical analysis for panels A-D were performed using one-way ANOVA test.