pone.0259643.g002.tif (205.84 kB)
Plasma concentrations of metronidazole and 2-hydroxymetronidazole in murine plasma.
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posted on 2021-11-09, 18:26 authored by Nina Zemanová, Kateřina Lněničková, Markéta Vavrečková, Eva Anzenbacherová, Pavel Anzenbacher, Iveta Zapletalová, Petra Hermanová, Tomáš Hudcovic, Hana Kozáková, Lenka JourováPlasma levels of metronidazole (A) and its primary metabolite 2-hydroxymetronidazole (B) were determined at 2nd, 6th and 24th hour after administration to mice (the 0 hour taken as a control).
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selected cytochromes p450remain mostly elusiverecent studies indicategut microbiota mayaltered gut microbiotaxlink "> microbiomegut microbiome modulatesgut microbiome affectssignificant metabolic organshown lower leveldrug metabolizing enzymesgut microbiomesignificant interactionparent drugbiotransformation enzymesvice versaresults hencereported earlierpharmacotherapy interventionsmutual relationshipmurine plasmamolecular mechanismsimmense potentialhigher levelshepatic cypscyps ).control specific30 %)
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