pntd.0010159.g001.tif (424.68 kB)
Phylogenetic tree of the most common eumycetoma causing agents.
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posted on 2022-02-04, 18:36 authored by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de SandeMadurella pseudomycetomatis, Madurella mycetomatis and Madurella tropicana belong to the order Sordariales, while Medicopsis romeroi and Falciformispora senegalensis belong to the order Pleosporales. Bolded characters indicate the fungal species used in this evaluation.
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pandemic response boxminimal inhibitory concentrationsmedicinal chemistry optimisationfungal orders sordarialesaminoquinolone derivative tafenoquinemadurella tropicana madurella pseudomycetomatis galleria mellonella find novel drugsfalciformispora senegalensis div >< pseven inhibited growthpromising drug candidatesmadurella mycetomatis benzimidazole carbamates fenbendazoleeumycetoma promising candidatesmycetomatis vivo vitro novel antifungalstreat eumycetomasignificantly prolongmycetos ).medicopsis romeroilike moleculeslarvae survivalfour compoundsfive speciescure ratescompounds activealso serve26 compounds
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