pone.0262419.g001.tif (338.7 kB)
Pedigrees of the five melanoma-prone families.
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posted on 2022-01-27, 18:32 authored by Felipe Fidalgo, Giovana Tardin Torrezan, Bianca Costa Soares de Sá, Bruna Durães de Figueiredo Barros, Luciana Facure Moredo, Renan Valieris, Sandro J. de Souza, João Pereira Duprat, Ana Cristina Victorino Krepischi, Dirce Maria CarraroTumor types are described beneath each individual, followed by the age of onset. Small black arrow indicates the index case of each family. The green arrow indicates the individuals who were subjected to WES analysis.
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variant pathogenicity predictionnew putative candidatesgenetic predisposition accounts2 affected individualspotential candidate genesprone families negativeprone families contributingcutaneous melanoma susceptibilitycutaneous melanoma predispositionincluding 7 lossdiv >< pprone familiesputative rolegenetic etiologyaffected relativesseveral genespenetrance genesmelanoma riskmelanoma casesbrazilian melanoma5 melanomawrn silico serpinb4 pot1 novel setnop10 nearly 10myo7a hrnr gene functionfunction variantsexome sequencingdozen moderatecdkn2a cdk4 biological pathwaysbap1
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