Pearson correlation coefficient between predicted and experimental B-factors for ENCoM and ANM.

A) The mean Pearson correlation is shown as a function of the β scaling factor for the three ENMs. B) The Entropic Signature using the best scaling factor for each model is compared to the mean square fluctuations (MSF). The p-values from paired Wilcoxon signed-rank tests are shown for pairs of the two types of predictions for every model and for every pair of models, only for the Entropic Signature predictions since they outperform the MSF.