pone.0195776.g001.tif (982.57 kB)
Patient flow-chart.
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posted on 2018-05-09, 17:30 authored by Jürg Schliessbach, Andreas Siegenthaler, Lukas Bütikofer, Andreas Limacher, Peter Juni, Pascal H. Vuilleumier, Ulrike Stamer, Lars Arendt-Nielsen, Michele CuratoloFlow-chart displaying study design and treatment allocation.
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trial Antidepressantsdrug metabolismdrug intakeimipramine effect2 hoursAnti-nociceptive effectsneuropathic painfuture studiesMultimodal QSTdouble-blinded placebo-controlled designtricyclic antidepressant imipraminemetabolizer statusCYP 2D genotypingimipramine 75 mg1.10 timestolterodine 1 mgPharmacogenetic influencesCIpressure pain detection thresholdsCYP 2Dmusculoskeletal pain conditionscytochrome P 450 2 D 6cytochrome P 4501.20 timesCYP 2D genotype30 minutestricyclic antidepressants
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