pone.0294603.g002.tif (1.71 MB)

Pathway mapping of the proteome signature.

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posted on 2024-02-29, 18:23 authored by Samantha M. Powell, Leah G. Jarsberg, Erin L. M. Zionce, Lindsey N. Anderson, Marina A. Gritsenko, Payam Nahid, Jon M. Jacobs

Differentially abundant serum proteins were pathway mapped across the longitudinal collection of baseline through 52 weeks. Hierarchical categorization is denoted by color and size.

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provided indicative markers proteins uniquely significant like growth factor immune modulated responses identify surrogate markers culture conversion status almost exclusively downregulated proteome signatures collapsed differential proteome signatures week results showed later time periods discrete expression profiles global proteome signature ms proteomic platform integrin signaling maintained treatment progression within statistical differences across 26 weeks respectively xlink "> serum xlink ">serum proteome proteome changes treatment progression time course severity signature expression dynamics compared across 52 weeks 26 weeks week timepoint treatment endpoints treatment 52 though interestingly sensitive lc pulmonary tuberculosis primarily focused metabolism annotations longitudinal analysis largest number initial effects infectious disease disease severity comprehensive assessment compared using better understanding also highlights

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