pone.0262667.g003.tif (2.6 MB)
Pathway enrichment analysis.
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posted on 2022-01-19, 18:31 authored by Eleni Petra, Justyna Siwy, Antonia Vlahou, Joachim JankowskiPathway enrichment analysis of the 16 shortlisted proteases along with the 69 protein precursors of the differentially excreted peptides was performed by the Reactome pathway database. The 10 most significant clusters are presented in different colours and the most significant term of each cluster is selected as a label. The associated proteases are highlighted in red colour.
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studies towards elucidatingrespective protease inhibitorsmolecular mechanisms underlyingmatrix metalloproteinases (<highlighted including membersurinary peptide profilesserine proteases (<303 urinary peptidesperformed using proteasixdiv >< pchronic kidney diseaseassociated transcriptomics datasetstranscriptomics datasetsassociated peptidesurinary peptidomekidney functionheart diseasesignificantly associatedseveral proteasesproteases involvedproteases activityinvolved proteasesurine peptidomestudy aimedstatistically analyzedsilico proteolytic eventspredicted basednephroseq databasemmp7 merops databasemade yetfully understoodfrequently observedextensively studiedcontrol studycollagen typesalso retrievedabundance changes>); laying
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