pone.0279821.s003.tif (5.45 MB)
Pathology analysis confirms consistency between PDXO and associated PDX, preserving original tumor features across different cancer types.
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posted on 2023-01-05, 18:41 authored by Xiaoxi Xu, Rajendra Kumari, Jun Zhou, Jing Chen, Binchen Mao, Jingjing Wang, Meiling Zheng, Xiaolong Tu, Xiaoyu An, Xiaobo Chen, Likun Zhang, Xiaoli Tian, Haojie Wang, Xin Dong, Zhengzheng Bao, Sheng Guo, Xuesong Ouyang, Limei Shang, Fei Wang, Xuefei Yan, Rui Zhang, Robert G. J. Vries, Hans Clevers, Qi-Xiang Lia) Typical cystic, compact, budding and grape-like organoid phenotypes were observed using bright-field microscopy (16x magnification); b) Bright field (top panel) and H&E staining (middle panel, 40x magnification) of PDXO models from different cancer types (colorectal, gastric, lung, pancreatic, liver and ovarian), and H&E staining of matching PDX (bottom panel).
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cancer stem cellspdx )/ organoidexisting pdx librarypdo ), drivenderived tumor xenograftimmune cell codiv >< pconfirmed high degree550 matched pairsmatched pairscarcinoma pdxcsc ),derived xenograftsvivo used extensivelytranslational oncologythroughput screeningsurrogate subjectspredictive modelspatients amenablelead compoundsinterchangeability ”including populationhts ).engineering enables
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