ppat.1011954.s003.tiff (1.01 MB)
Pathogenicity of LCLs in 5-week-old NOG mice.
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posted on 2024-02-01, 18:30 authored by Ken Sagou, Yoshitaka Sato, Yusuke Okuno, Takahiro Watanabe, Tomoki Inagaki, Yashiro Motooka, Shinya Toyokuni, Takayuki Murata, Hitoshi Kiyoi, Hiroshi Kimura(A) Overall survival for mice inoculated with LCLs-WT or LCLs-dBNRF1. The time for 50% survival was 28 days for LCLs-WT and 35 days for LCLs-dBNRF1. (B) Histochemistry of the intraperitoneal tumors stained with hematoxylin and eosin (top), and analyzed by EBER in situ hybridization (middle) and LMP1 immunohistochemistry (bottom). The images shown are representative of two independent experiments with similar results. Scale bar, 100 μm.
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reactive oxygen speciesmice xenograft modellytic replication contributesinducible protein 27conserved among gammapromotes cell proliferationlymphoblastoid cell linesseq analyses revealedlytic gene bnrf1div >< pcell deathfindings revealedwt resultedwt ).vivo vitro significantly decreasedseveral malignanciesprimary infectionlatent factorsimportant roleexcessive productionexamined whethercausally associatedcancer developmentbnrf1 elicitedbarr virusalso confirmed
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