pntd.0010159.g003.tif (999.64 kB)
Pandemic response box compounds exhibiting potency at 25 μM against the tested fungal species.
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posted on 2022-02-04, 18:36 authored by Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de SandePanel A divides the compounds into their respective groups as indicated in the Pandemic Response Box. Most compounds exhibiting potency at 25 μM falls under the antifungals and antibacterial. Less than 21% are antivirals. No antivirals inhibit M. romeroi growth at 25 μM. Panel B displays a Venn diagram. Four compounds–Fenbendazole, Carbendazim, Tafenoquine and MMV1578570 were able to inhibit all 5 fungal species tested here.
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pandemic response boxminimal inhibitory concentrationsmedicinal chemistry optimisationfungal orders sordarialesaminoquinolone derivative tafenoquinemadurella tropicana madurella pseudomycetomatis galleria mellonella find novel drugsfalciformispora senegalensis div >< pseven inhibited growthpromising drug candidatesmadurella mycetomatis benzimidazole carbamates fenbendazoleeumycetoma promising candidatesmycetomatis vivo vitro novel antifungalstreat eumycetomasignificantly prolongmycetos ).medicopsis romeroilike moleculeslarvae survivalfour compoundsfive speciescure ratescompounds activealso serve26 compounds
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