pntd.0009940.g001.tif (592.23 kB)
PVL in PBMCs does not correlate with the clinical status in HTLV-1 infected subjects.
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posted on 2021-11-12, 18:36 authored by Brenda Rocamonde, Nicolas Futsch, Noemia Orii, Omran Allatif, Augusto Cesar Penalva de Oliveira, Renaud Mahieux, Jorge Casseb, Hélène Dutartre(A) Proviral load (PVL) of the HTLV-1 asymptomatic carriers (AC) and HAM/TSP patients. (B) Graph representing motor scores (IPEC and Osame) and PVL in HAM/TSP patients. (C) Correlation between PVL of HTLV-1-infected individuals and the age at the time of the analysis.
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tropical spastic paraparesissup >+pdc producing ilcell leukemia virushigher ifnγ responsivenessdevastating neurodegenerative diseasemonocytes producing mipincluding asymptomatic carriersdiv >< ptsp patients comparedtsp blood samplesblood samplesasymptomatic carrierstsp patientstsp comparedhigher frequencydisease occurrencedisease manifestationsteady statesignaling pathwaypotential consequencenk cellsneuroinflammatory statusmechanism underlyinglower responselike receptorinflammatory responseinfected volunteersincreasing numberincreased sensitivityimmune cellseffective treatmentcorticosteroid treatmentsadaptive compartment
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