pgen.1009774.s007.tif (1.98 MB)
PTEN variant function in the wing assay compared to developmental delay assay, HEK and yeast assays.
figure
posted on 2021-09-07, 17:45 authored by Payel Ganguly, Landiso Madonsela, Jesse T. Chao, Christopher J. R. Loewen, Timothy P. O’Connor, Esther M. Verheyen, Douglas W. AllanA heatmap comparing the relative function of PTEN variants in available assays; wing size assay in Drosophila, developmental delay assay (time to eclosion) in Drosophila, yeast growth dependent on PIP3 to PlP2 hydrolysis, ΔVAC14 yeast sentinel and the ratio of pAKT/AKT immunoreactivity levels in HEK (where no PTEN = 0 and PTEN-WT = 1).
(TIF)
History
Usage metrics
Categories
Keywords
recent published datagenetic interaction approachdiv >< passessing defined genegene variant discoverypredicted functional categoriesbecoming common placehuman cell lineassay correctly assignedclinical interpretation alignedworking group guidelinesoffers great potentialdrosophila melanogaster clinical variant interpretationestablished assays ’.human variants adherentpowerful assay platformbenign pten variantsclinical interpretationdrosophila established assayspten benign variantspten variantsinterpretation gapfunctional consequencebecoming routinevariant functionexperimental assaysassays reproducibleassay platformvariants correlatedusefully interpretremains difficultremains challengingincrease confidencehigh numbersdisease relevancedisease mechanismcellular growthakt signalingaccurate assessment
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC