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PSSM Analysis subdivides Sct4 into Prx1 and Prx6 groups based on distinctive active site features.

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posted on 10.02.2017, 18:25 by Angela F. Harper, Janelle B. Leuthaeuser, Patricia C. Babbitt, John H. Morris, Thomas E. Ferrin, Leslie B. Poole, Jacquelyn S. Fetrow

(A) A score distribution of the Sct4 Search1 results is shown with bars colored based on known functional annotation. The yellow and green boxes identify the groups distinguished by PSSM Analysis. (B) Search2 score distributions show the results of the subsequent MISST iteration, in which profiles of sequences in each of the yellow and green boxes were created and used in separate searches.