PIVKA II espression in PDAC tissue slides.

A) H&E staining of PDAC sections; the tissue is intact and composed entirely of tumor cells, pleomorphic and with altered cytoplasmic nucleus ratio. B) IF analysis of the PIVKA II of PDAC tissue. Several cells are marked, and the signal appears cytoplasmatic and dotted, mainly distributed in the perinuclear area. DAPI was used to highlight cell nucleus. Arrowheads indicate cytoplasmic dots. Bar: 20 μm. H&E = Hematoxylin and eosin PDAC = Pancreatic adenocarcinoma IF = immunofluorescence DAPI = 4′,6-diamidino-2-phenylindole.