ppat.1009030.s006.tif (186.27 kB)
PGLYRP1 dependent killing of B. burgdorferi.
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posted on 2020-11-11, 18:34 authored by Akash Gupta, Gunjan Arora, Connor E. Rosen, Zachary Kloos, Yongguo Cao, Jiri Cerny, Andaleeb Sajid, Dieuwertje Hoornstra, Maryna Golovchenko, Natalie Rudenko, Ulrike Munderloh, Joppe W. Hovius, Carmen J. Booth, Christine Jacobs-Wagner, Noah W. Palm, Aaron M. Ring, Erol FikrigHuman PGLYRP1- His8 (0–66.7 ng/μl) was incubated with B. burgdorferi (1x105) for 48 hours in 96-well plate, keeping final volume 300 μl. The viability was assessed by BacTiter Glo assay. The graph shows effect of human PGLYRP1 concentration on Borrelia (BbN40). Results from one independent experiment performed in triplicates are shown here.
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exhibits borreliacidal activityPeptidoglycan Recognition Protein 1burgdorferi infectionspirochete Borrelia burgdorferiIFNburgdorferi sensu latosystems biology approachsecretome library screenDiverse host responses influenceCXCLyeast display screeningserum IgG levelsLyme borreliosis Lyme diseasePGLYRP 1yeast display library
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