pone.0294603.g001.tif (4.43 MB)

Overview of the serum proteome study.

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posted on 2024-02-29, 18:23 authored by Samantha M. Powell, Leah G. Jarsberg, Erin L. M. Zionce, Lindsey N. Anderson, Marina A. Gritsenko, Payam Nahid, Jon M. Jacobs

(A) Timeline of the different patient population serum collection timepoints relative to treatment arm for a total of 30 patients. (B) Hierarchical clustering heatmap of the composite 676 proteins which exhibited differential abundance within the measured grouped timepoints, stratified by treatment type. Red to blue color gradient corresponds to higher to lower relative protein abundance values.

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provided indicative markers proteins uniquely significant like growth factor immune modulated responses identify surrogate markers culture conversion status almost exclusively downregulated proteome signatures collapsed differential proteome signatures week results showed later time periods discrete expression profiles global proteome signature ms proteomic platform integrin signaling maintained treatment progression within statistical differences across 26 weeks respectively xlink "> serum xlink ">serum proteome proteome changes treatment progression time course severity signature expression dynamics compared across 52 weeks 26 weeks week timepoint treatment endpoints treatment 52 though interestingly sensitive lc pulmonary tuberculosis primarily focused metabolism annotations longitudinal analysis largest number initial effects infectious disease disease severity comprehensive assessment compared using better understanding also highlights

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