Overview of detailed intermolecular interactions governed by ATP and NLRPNACHT models.

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Overview of detailed intermolecular interactions governed by ATP and NLRP^NACHT models.

2018-12-20T18:34:17Z (GMT) by Jitendra Maharana Debashis Panda Sachinandan De

The NLRP^NACHT models are displayed in cartoon; ATPs are visualized in light blue ball-sticks and the residues interacting within 5Å of ATP are visualized in white stick model. The black dotted lines represent the intermolecular polar contacts. The key interacting residues (of proposed ATP-binding motifs) are presented in bold font and colored based on their physicochemical parameters.

Keyword(s)

ATP-Mg oligomerization domain NLRP-signaling mechanism ATPase superfamily PRR inflammasome activity sensor-adaptor-effector interactions C-terminal end novel inhibitors NLRP NACHT models residue ATP-binding pocket NLRP-NACHT 3 D models NOD LRR cytosolic pattern recognition receptors bioinformatics approaches ADP mutagenesis data protein modeling AAA pathogen recognition bioinformatics approaches Nucleotide-binding EBD PhhC W motif dynamics simulations G F xxxxRxx Y F motif structural-dynamic features

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