pone.0254305.g008.tif (304.19 kB)
Overexpression of AT1 receptor.
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posted on 2021-09-30, 17:30 authored by Nikita Lomis, Susan Westfall, Dominique Shum-Tim, Satya PrakashAT1 expression in normal, hypoxic and hypertrophic H9c2 cells. Results are represented as mean ± SD (n = 3). ****p<0.0001 was considered highly significant based on Tukey’s posthoc analysis.
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lacking target specificityexhibits low bioavailabilityexhibit superior targetingcovalent conjugation reaction9 ± 18 ± 2improves myocardial contractility4 ± 14 %, respectively2 ± 4overexpressing at1 receptorsh9c2 cells treateddrug delivery characteristicsdiv >< pcongestive heart failuretargeted cardiac uptakeheart failureh9c2 cellstargeted drugtargeted deliverymyocardial infarctioncardiac functionzeta potentialvs 44vivo vasodilatory effectssurface functionalizedsignificantly highernanoparticle sizeintracellular uptakehypertrophic conditionscumulative releaseangiotensin ii7 nm7 mv24 hrs
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