pone.0258951.g001.tif (1.14 MB)
Over expression of caveolin-1 in radioresistant A549 lung cancer cells.
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posted on 2021-11-11, 18:35 authored by Dominic Leiser, Santanu Samanta, John Eley, Josh Strauss, Michael Creed, Tami Kingsbury, Paul N. Staats, Binny Bhandary, Minjie Chen, Tijana Dukic, Sanjit Roy, Javed Mahmood, Zeljko Vujaskovic, Hem D. Shukla(A) Clonogenic survival assay of parental and radio resistant A549 human lung cancer cell treated with 2, 4 and 6 Gy of radiation. (B), Percent survival of A549 parental and radioresistant cells treated with 2, 4 and 6 Gy of radiation. (C), Survival curve of A549 parental (blue) and radioresistant (Red) cells representing absorbed radiation dose and survival fraction using Linear-Quadratic Model. (D), Immunoblot analysis of Caveolin-1 (21 kDa) in the cell lysate of A549 parental (lane S), radio resistant (lane R), and CAV-1 overexpressed cells (lane OE).
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stat signaling pathwayslung cancer patientsdiscovered higher levelcomplex multifactorial mechanismheterogeneous tumor siteradiation therapy playsradio sensitive phenotypepresent investigation caveolindiv >< pparental a549 cellsexpressed a549 cellsgene expression analysis1 overexpressed cellsradiation treatment responsea549 parentalhighly expressedenhanced expressiontumor radioresistancetumor progressiontumor aggressiontreatment failureprecision medicinepoor survivalpoor prognosisnsclc ).missense mutationmeasure caveolinmajor causedna damagedemonstrated amplificationcytoskeleton proteinsclonal selectioncas9 knockout950 pg450 pg1 protein1 1 (<
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