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Optimization for the latent dimension.

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posted on 2023-11-27, 19:10 authored by Hoda Akl, Brooke Emison, Xiaochuan Zhao, Arup Mondal, Alberto Perez, Purushottam D. Dixit

The optimized value is Δ2 = (〈Hmin from generated ensemble to MSA〉−〈Hmin within MSA〉)2. Each box plot represents 10 runs for each latent dimension. The optimum latent dimension for DHFR is 64, for P53 is 17 and for and for MTOR is 12.

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    PLOS Computational Biology

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    unlike current methodsstable 3d structuremodeling moderately sizedlow sequence coverageinformative latent spacecorresponding natural ensemblesamino acid covariationgenerative nonlinear tensoraccurate generative modeldiv >< pprotein sequence familiesprotein familiesgenerative modelsprotein scientistsrelated obstacleslarge proteinsimportant toolfactorization engineers alike

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