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Odds ratio (OR1) of disease were calculated for individuals having only 1 copy of the listed CEH among individuals who have no (or no other) copies of an (H+) carrying CEH.

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posted on 2021-08-09, 17:29 authored by Douglas S. Goodin, Jorge R. Oksenberg, Venceslas Douillard, Pierre-Antoine Gourraud, Nicolas Vince

Comparisons of the OR1s for the different CEHs listed in the Table. The numbers in the Table represent the z-scores comparing, at the point of intersection, the OR1 in the column to that in the row. Positive numbers indicate that the OR1 for the column CEH is greater than that for the row. Absolute z-values (|z| ≥ 3.0) are highlighted in dark blue (negative) or dark red (positive); absolute z-values (2.0 ≤ |z| < 3.0) are highlighted by medium blue (negative) or medium red (positive); absolute z-values (1.0 ≤ |z| < 2.0) are highlighted in light blue (negative) or light red (positive); absolute z-values (|z| < 1.0) are indicated by asterisks. CEHs carrying the (H+) haplotype are highlighted in yellow; CEHs carrying the DRB1*15:01~DQB1*06:02~a36 haplotype are highlighted in green; CEHs carrying the DRB1*03:01~DQB1*02:01~a6 haplotype are highlighted in orange; CEHs carrying the DRB1*03:01~DQB1*02:01~a2 haplotype are highlighted in light orange; CEHs carrying the DRB1*04:01~DQB1*03:01~a3 haplotype are highlighted in light green. Benjamini-Hochberg adjustment requires (|z| > 3.3) for significance. Because the CEHs are listed in descending order of their frequency, comparisons in the upper left-hand side of the Figure have the greatest statistical power.

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