Novel TEM findings in IC/BPS urothelium.

(A) red blood cells extravasation (black arrows) from lamina propria to urothelium with interrupted basement membrane (arrowheads, bar: 10um). This bladder specimen was obtained before hydrodistention. (B) Macrophage in the urothelium (arrowhead, bar: 2um). (C) Widening of lateral interstitial space between adjacent umbrella cells s with loose interdigitation (black arrows, bar: 2um) in both umbrella and intermediate cells.