ppat.1009197.s005.tif (1.57 MB)
Mutagenesis screens identify residues critical for CSPG4-binding.
figure
posted on 2021-01-28, 18:27 authored by Zhenrui Pan, Yuanyuan Zhang, Jianhua Luo, Danyang Li, Yao Zhou, Liuqing He, Qi Yang, Min Dong, Liang TaoThe sensitivities of the HeLa CSPG4–/–(A) and FZD1/2/7–/–(B) cells to TcdB1 and twenty-one TcdB1 mutants. The fitting curves for mutants ADNGR441-445EENIS, G624T/G626S, and S638D/I639R are marked by arrows. The percentage of rounded cells were plotted over toxin concentrations. (Error bars indicate mean±s.d., n = 6)
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