pntd.0009924.g003.tif (397.77 kB)
Multiple regression model to estimate the bacterial load in skin biopsies based on the R-value of αPGL-I test, the number of lesions and the nasal swab qPCR result.
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posted on 2021-11-10, 18:25 authored by Sofie Marijke Braet, Anouk van Hooij, Epco Hasker, Erik Fransen, Abdou Wirdane, Abdallah Baco, Saverio Grillone, Nimer Ortuno-Gutierrez, Younoussa Assoumani, Aboubacar Mzembaba, Paul Corstjens, Leen Rigouts, Annemieke Geluk, Bouke Catherine de JongR-values for the αPGL-I test on fingerstick blood; HBL = high bacterial load (≥50,000 bacilli in a skin biopsy); multibacillary as per WHO operational classification; paucibacillary as per WHO operational classification.
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world health organizationwithout microbiological confirmationhigh bacterial burdenclinical cardinal signsbacterial load measuredbacterial load determined2017 – 2018invasive nasal swabslit skin smearsdiv >< pminimally invasive samplingfingerstick blood samplesidentify leprosy patientscomoros fingerstick bloodnasal swabsskin biopsyskin biopsiesstrong correlationspecific antibodiesresults showongoing transmissionmay leadleprosy patientsleprae lacks sensitivityigm levelshansen ’first studyentirely basedendorsed diagnosisdemonstrated potentialcounting lesionscomlep studyalso known310 patients151 ),000 bacilli
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