pcbi.1011151.g007.tif (822.58 kB)
Model version 4.0.0 fitted to pseudo-time courses of RPE-1 cells.
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posted on 2024-01-08, 18:23 authored by Paul F. Lang, David R. Penas, Julio R. Banga, Daniel Weindl, Bela NovakExperimental measurements and simulation results using estimated parameters. For better visibility, only every 10th measurement is shown. a, c, e Nuclear compartment. b, d, f Cytoplasmic compartment. g Convergence curve. PEtab problem incl. parameter table and SBML file with optimized parameters are available in the /versions/v4.0.0/ directory of the cell_cycle_petab GitHub repository.
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powerful computational toolsobtained excellent agreementsimprove parameter identifiabilitycomputational models providemammalian cell cyclefull cell cyclecomprehensive model structurecell cyclemodel structurexlink ">work aimsvalidation methodologytwo compartmentstime coursessystemic descriptionreusable ruleresolved dynamicsqualitatively explainspetab specificationparticularly systematicmodel parametersdrug discovery16 observables1 cells
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