ppat.1012036.s001.tif (881.16 kB)
Metabolomic analysis of the medium of CVB3 infected Hela cells.
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posted on 2024-03-08, 18:21 authored by Lonneke V. Nouwen, Martijn Breeuwsma, Esther A. Zaal, Chris H. A. van de Lest, Inge Buitendijk, Marleen Zwaagstra, Pascal Balić, Dmitri V. Filippov, Celia R. Berkers, Frank J. M. van Kuppeveld13C-glucose isotope tracing study in mock- and CVB3-infected HeLa R19 cells (three replicates; one experiment; MOI 5). Cells were infected, lysed at 2,4,6 or 8 hpi and measured by LC-MS to identify metabolites and quantify the different isotopologues. The different isotopologues are not distinguished in this Figure. Heatmap showing log2 fold changes of extracellular metabolites during CVB3 infection using.
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viruses actively reprogramsufficient building blockskey enzymes involvedde novo glucose tracing metabolomicsdiv >< p13 picornaviruses picornaviruses —metabolomics datavirus replicationusing steadyrelatively littlepurine metabolitesproviding insightprovide evidencephosphorylation statusnucleotide recyclingnucleic acidslarge familyinfected cellsidentify alterationsenveloped positiveenterovirus genusencephalomyocarditis virusemcv ),coxsackievirus b3cardiovirus genus
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