pone.0259643.g001.tif (137.36 kB)
Metabolism of metronidazole in humans.
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posted on 2021-11-09, 18:26 authored by Nina Zemanová, Kateřina Lněničková, Markéta Vavrečková, Eva Anzenbacherová, Pavel Anzenbacher, Iveta Zapletalová, Petra Hermanová, Tomáš Hudcovic, Hana Kozáková, Lenka JourováIn the human liver, metronidazole is metabolized by side-chain hydroxylation, oxidation or glucuronidation to form more polar metabolites. Metronidazole can also undergo modification by gut microbiota producing reduced metabolites such as N-(2-hydroxyethyl)-oxamic acid and acetamide.
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selected cytochromes p450remain mostly elusiverecent studies indicategut microbiota mayaltered gut microbiotaxlink "> microbiomegut microbiome modulatesgut microbiome affectssignificant metabolic organshown lower leveldrug metabolizing enzymesgut microbiomesignificant interactionparent drugbiotransformation enzymesvice versaresults hencereported earlierpharmacotherapy interventionsmutual relationshipmurine plasmamolecular mechanismsimmense potentialhigher levelshepatic cypscyps ).control specific30 %)
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